Phenotypic Characterization of Trisomy 12 Monoclonal B-Cell Lymphocytosis
نویسندگان
چکیده
منابع مشابه
Monoclonal B-Cell Lymphocytosis
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 10(9)/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenot...
متن کاملMonoclonal B-cell lymphocytosis☆
Chronic B-cell lymphocytic leukemia (B-CLL) represents 0.9% of all new cancers. It is estimated that there will be almost 15 000 new cases and 4600 deaths due to CLL in 2015 in the USA.1 The median ages at diagnosis and death are 71 years and 80 years, respectively.1 The criteria that define the diagnosis of B-CLL include the presence of at least 5 × 106 B lymphocytes/L with the peculiar CLL ph...
متن کاملMonoclonal B-cell lymphocytosis.
The incidence and presenting features of chronic lymphocytic leukemia (CLL) have changed significantly over the last century. Routine diagnostic techniques can now detect very low levels of CLL phenotype cells. Monoclonal B-cell lymphocytosis (MBL) is a relatively recent diagnostic category encapsulating individuals with an abnormal B-cell population but not meeting the diagnostic criteria for ...
متن کاملClinical aspects of monoclonal B-cell lymphocytosis.
BACKGROUND Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic precursor condition for chronic lymphocytic leukemia (CLL). It is defined by the presence of small clones of aberrant B cells in the peripheral blood, with a total B-cell count below the threshold for diagnosis of CLL (<5.0x10(9) cells/L). METHODS The authors review current literature on the prevalence of MBL, and the clinica...
متن کاملNew Insights into Monoclonal B-Cell Lymphocytosis
Monoclonal B-cell lymphocytosis (MBL) is a premalignant condition characterized by the presence of less than 5000/μL circulating clonal B cells in otherwise healthy individuals. Three subcategories have been identified according to the immunophenotypic features: CLL-like, CD5(+) atypical, and CD5(-) MBL. CLL-like MBL is by far the most frequent and best studied category and further divided in l...
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ژورنال
عنوان ژورنال: Cytometry Part B: Clinical Cytometry
سال: 2017
ISSN: 1552-4949
DOI: 10.1002/cyto.b.21517